The value of salivary soluble CD44 level determination in oral malignant and potentially premalignant lesions

Objective: order to determine the validity of sCD44 ELISA test on saliva and its effectiveness in diagnosing and predicting prognosis of oral cancer and premalignant lesions Design: prospective comparative clinical trial
Patients & Methods: Patients with suspected lesions for cancer were subjected to sCD44 ELISA test on saliva then followed by biopsy and histopathological examination. Results were compared to healthy participants to check the difference
Results: Salivary sCD44 level was detected in saliva of all patients and in the cancer group salivary sCD44 level (48.05±20.66 ng/ml) was much higher than that of the control group (12.37±3.82 ng/ml) with a statistically significant difference. On the other hand, when the mean level of salivary sCD44 was compared between the premalignant without dysplasia and the premalignant with dysplasia groups, salivary sCD44 level in the premalignant with dysplasia group …